An even broader range of clinical presentations has been recently related to mutations in the coiled-coil-helix-coiled-coil-helix domain containing 10 (CHCHD10) gene, encompassing not only ALS without cognitive impairment, ALS/FTD or FTD (~1 % of cases), but also parkinsonism, cerebellar ataxia and mitochondrial myopathy [40–43]. This evidence concerns the gene CHCHD10 and Parkinson disease.