Indeed, we have found that the proteomic profiles of FA and FTC from our cohort are highly similar; however, we also found that the elevated expression of the extracellular protein TGFBI was able to differentiate 6 out of 8 FTC from FA specimens (Fig. 6), which comprise the two main types of thyroid tumours in the indeterminate category of FNA biopsies. Here, TGFBI is linked to thyroid tumor.