The comparison of PTC tumours with normal samples readily identified many proteins commonly associated with the papillary histotype (e.g. annexin A1, thymosin β10, galectin-3, cytokeratin 19, ICAM-1, UDP-glucose 4-epimerase, cellular retinoic acid-binding protein 1, fibronectin, S100A65, 9, 10, 11, 12, 15, 23, 24; see Supplementary Table S4), hence validating the analyses shown here. The gene discussed is ANXA1; the disease is neoplasm.