FTC and PTC tumours shared dysregulation of 39 proteins with respect to normal thyroid tissue (Supplementary Table S6), including anterior gradient homolog 2 (AGR2), tenascin, extracellular superoxide dismutase (SOD3), 14-3-3 gamma, immunoglobulin superfamily containing leucine-rich repeat protein (ISLR), biotinidase and trefoil factor 3 (TFF3). The gene discussed is ISLR; the disease is neoplasm.