Metachromatic leukodystrophy (MLD) and globoid cell leukodystrophy (GLD or Krabbe disease) are recessive lysosomal storage diseases (LSD) caused by arylsulfatase A (ARSA) and galactosylceramidase (GALC) deficiency, respectively, leading to severe demyelination, neurodegeneration and premature death, and currently lacking any approved treatment. Here, ARSA is linked to lysosomal storage disease.