Specifically, the kinase activity of nuclear-targeted FAK in squamous cell carcinoma (SCC) cells drives exhaustion of CD8 + T cells and recruitment of regulatory T cells (Tregs) in the tumor microenvironment by regulating chemokine/cytokine and ligand–receptor networks, including via transcription of Ccl5, which is crucial. Here, CCL5 is linked to squamous cell carcinoma.