One interesting gene with a mechanism of pathogenesis for thrombocytopenia is ADAMTS13. Variants in the metalloproteinase ADAMTS13 are the genetic cause of Upshaw–Schulman syndrome, alternatively known as congenital thrombotic thrombocytopenic purpura (TTP) [51]. This evidence concerns the gene ADAMTS13 and thrombotic thrombocytopenic purpura.