Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by two pathological lesions: deposition of β-amyloid peptides (Aβ) as amyloid plaques and the microtubule-associated protein tau in the form of paired helical filaments in neurofibrillary tangles (NFTs) [1]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.