EMT plays important role during embryogenesis, wound healing and tumor progression and is characterized by the loss of epithelial marker E-cadherin and gain expression of mesenchymal markers such as N-cadherin, vimentin and fibronectin etc. Repression of epithelial phenotype and gain of mesenchymal phenotype are regulated by many molecules, including master transcription factor regulators, Snail, Slug, Twist, and Zeb-1 [7, 8]. The gene discussed is CDH1; the disease is neoplasm.