BCL3 and B-cell chronic lymphocytic leukemia: Cloning of chromosomal breakpoints found in chronic lymphocytic leukemia cells demonstrated that the t(14;19) chromosomal translocation results in the juxtaposition of the BCL3 gene with the immunoglobulin (Ig) heavy locus leading to the overexpression of Bcl-3 in leukemic cells [19,20,21].