The receiver operating characteristic (ROC) curve of plasma TIMP-1 levels, which represents the relationship between the sensitivity and the specificity of plasma TIMP-1 in detecting liver fibrosis, showed that a cutoff value of 89 ng/mL resulted in 91.67% sensitivity and 83.33% specificity for HCV monoinfected and 100% sensitivity and 84.43% specificity for HIV/HVC coinfected patients. Here, TIMP1 is linked to Hepatic fibrosis.