The NPY y6 receptor only exists as a functional receptor in the mouse and rabbit.53 The NPY Y4 receptor mRNA is the least abundant and has the most restricted distribution pattern of all NPY receptor subtypes in the central nervous system.40 In addition, the available agonist for the human NPY Y4 receptor has a short mean half-life of only approximately 6 minutes, limiting its bioactivity in vivo.2 NPY has been shown to be involved in antinociception in different pain models,28,29,38 although not studied yet in migraine. The gene discussed is NPY; the disease is migraine disorder.