In order to determine if there was crosstalk between FN and the IFN-α signaling pathway, NC-KD cells and FN-KD cells were transfected with pIFN-α2-Luc, which carries an IFN-α2 subtype promoter, along with the indicated constructs expressing genes involved in endogenous IFN-α signaling, followed by mock infection or SeV infection. This evidence concerns the gene IFNA2 and infection.