c-MYC lesions in the DEABM are also to occur early in the mutational history of ER- tumors, corresponding to data on c-MYC’s association with higher Ki-67 indexes, larger tumors and comedo-type in DCIS lesions, indicating that it may play an early role in fast-growing, high-risk DCIS lesions that are predisposed to becoming invasive [57, 58]. This evidence concerns the gene MKI67 and ductal breast carcinoma in situ.