It suggested that HDAC4 exhibited nuclear influx in the HE group, and according to other research the beta-adrenergic signaling pathway to HDAC4 (beta-adrenergic receptor → cAMP → PKA → HDAC4 phosphorylation at the PKA sites) may play a role in such process[35]. The gene discussed is HDAC4; the disease is hereditary elliptocytosis.