After 2 weeks, the expression of PGC-1α, p-AKT (Fig 3), HDAC4 and nuclear HDAC4 proteins (Fig 4) was no significant difference between the groups; however, there was a tendency towards an increase in the PGC-1α protein expression in the HH and HE groups. The gene discussed is AKT1; the disease is hereditary elliptocytosis.