In particular, overexpression of JMJD2B exhibits oncogenic activity in various human cancers, including prostate, breast, colon and gastric cancers.13, 14, 15, 16, 17 In addition, JMJD2B was found to be necessary for self-renewal of embryonic stem cells and induced pluripotent stem cell generation.18 The gene discussed is KDM4B; the disease is gastric cancer.