TGFB1 and schizophrenia: Bone morphogenic proteins are members of the TGF-β protein family of extracellular ligands,62 important in the neuronal protection against both apoptosis and excitotoxicity.63 The fidelity of these pathways are crucial for normal nervous system development and their disruption has been suggested to underlie schizophrenia pathology.63 Finally, glucocorticoids, a major subclass of steroid hormones, regulate a large number of immune, metabolic, cardiovascular and behavioral functions.