CDKN2A and cancer: In the significantly mutated genes, we determined that KRAS (G13D), PIK3CA (E545), TP53 a splicing site mutation, APC (E854fs), KMT2C (E141G, K339N, P309S, and Y816_I817delinsX), SETBP1 (Q1558L), and NCOR1 (S63L) were ubiquitous mutations, whereas CDKN2A (D74A), SMAD4 (W168X), NCOR1 (N208K), KMT2C (G315C and K306fs) and INHBA (V58I) were specific to the primary cancer.