In addition, the expression of various adipocytokines—such as interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1), and adiponectin (APN)—promotes crystal formation by elevating OPN expression, which associates with the calcium oxalate (CaOx) stone matrix in MetS [11]. This evidence concerns the gene CCL2 and metabolic syndrome.