35 (4) Coffee consumption can decreased inflammation marker, such as the level of IL-18, c-reactive protein and E- selectin. Several compounds of coffee can also inhibit the activation of nuclear factor kappa B (NF-κB), that is the key transcription factor of inflammatory process.36,37 (5) Experiment showed that coffee component cafestol, kahweol, and caffeine can induce apoptosis. 38 These molecular mechanisms could well explain our findings in our meta-analysis that high coffee consumption with a decreased pancreatic cancer risk. This evidence concerns the gene IL18 and pancreatic neoplasm.