To fill this gap, we developed and characterized a mouse model of lethal and nonlethal ZIKV infection in 3-, 5-, and 11-week-old immunocompromised mice lacking the receptor for type I interferon (IFN α/β) (A129 mice) or types I and II IFN (IFN α/β/γ) (AG129 mice). Here, IFNA1 is linked to Zika virus infectious disease.