The final diagnosis was laboratory-confirmed dengue fever caused by DENV-2 as confirmed by nested PCR and recovery of DENV-2 by mosquito inoculation, and corroborated with detection of an appropriate secondary antibody response to DENV (AFRIMS DENV IgM 83 ELISA units and IgG 252 ELISA units in a convalescent specimen). Here, CD40LG is linked to dengue disease.