CDH1 and metastatic malignant neoplasm: E-cadherin the major cadherin implicated in epithelial cell-cell adhesion, is associated with invasion and, more interestingly, it is commonly re-expressed by metastatic cancer cells to recover the adhesion complexes that are temporarily lost during the Epithelial-Mesenchymal Transition (EMT), which is required for effective dissemination25.