Previous studies demonstrated that specific PI3K or Akt inhibitors significantly suppressed the enhanced expression of Nrf2 as well as its cytoprotective effect induced by ADTM, which is a danshensu derivative with a similar structure to that of danshensu, on t-BHP-induced cell injury in H9c2 cells and myocardial injure in rat ischemia model59. The gene discussed is AKT1; the disease is ischemia.