In tumorigenesis, NCAM1+CD133−marks SIX2+ blastema that includes the ALDH1+ WTcancer stem/initiating cells, while NCAM1+CD133+ andNCAM1−CD133+ specifying early and lateepithelial differentiation, are severely restricted in tumor initiation capacity andtumor self-renewal. Here, PROM1 is linked to neoplasm.