In tumorigenesis, NCAM1+CD133−marks SIX2+ blastema that includes the ALDH1+ WTcancer stem/initiating cells, while NCAM1+CD133+ andNCAM1−CD133+ specifying early and lateepithelial differentiation, are severely restricted in tumor initiation capacity andtumor self-renewal. The gene discussed is NCAM1; the disease is neoplasm.