eEF2K (NM_007908.4) is a Ca2+/calmodulin-dependent protein kinase that regulates JNK (c-jun N-terminal kinase) and NF-κB (nuclear factor-kappa B) p65 phosphorylation as well as reactive oxygen species (ROS) production and also affects the development of hypertension [37, 38]. The gene discussed is MAPK8; the disease is hypertensive disorder.