ROS produced by lipoxygenases and NOX regulate pro-inflammatory responses in allergic airway inflammation [6], while NADPH:quinone oxidoreductase 1 (NQO1) upregulation is a Nrf2-dependent process relevant to macrophage-derived oxidants involved in the pathogenesis of ozone-induced oxidative stress, airway inflammation, and emphysema [65,66]. This evidence concerns the gene NQO1 and pulmonary emphysema.