APP and Alzheimer disease: Aberrant neuronal hyperexcitability has been observed in cortical and hippocampal neuronal networks of patients with early AD [150] and FAD AD mouse models with heightened levels of APP and Aβ [21, 41–44, 151]; this is also consistent with reports that patients with early AD and FAD animal models exhibit epileptic seizures [21, 45, 152–160].