CD4 and neoplasm: According to importance of CD4+ helper T-cells in antitumor immunity by promoting the permanence of memory CD8 T-cells [53], isolation of regulatory T-cells (Treg) based on CD4+ CD25+ CD127low CD45RA+ from tumor microenvironment and reprogramming them into iPSCs and then generation of CD4+ helper T-cells may be an effective strategy for ACT [56].