Sielicka-Dudzin et al. showed that DATS induces cell death of prostate cancer cells (PC-3) via JNK1-dependent ROS formation and Itch-dependent ferritin degradation, while DATS-induced cell cycle arrest in DU145 cells is associated with delayed nuclear translocation of cyclin-dependent kinase 1 [60, 61]. The gene discussed is MAPK8; the disease is Familial prostate cancer.