PDCD1 and neoplasm: PFS benefit was consistent in subgroup analyses independent of Memorial Sloan-Kettering Cancer Center (MSKCC) risk group and Eastern Cooperative Oncology Group (ECOG) status, organ involvement including bone and tumor burden, and extent of prior VEGFR-TKI and prior programmed cell death protein 1 (PD-1)/PD-L1 therapy13.