It has been only observed in patients with myelodysplastic syndrome that SF3B1 and SRFS2 mutations are associated with a downregulated expression of miRNAs derived from the putative 5′-tailed mirtrons hsa-miR-3605-5p and hsa-miR-4728-5p, respectively [5]. This evidence concerns the gene SF3B1 and myelodysplastic syndrome.