As serum IGFBP-4 correlated with eGFR in patients with LN, and since it has been reported that IGFBP-4 is increased in patients with chronic renal failure, [34, 35] we next explored if elevated serum IGFBP-4 is indicative of chronic lupus nephritis. This evidence concerns the gene IGFBP4 and lobular neoplasia.