Using a panel of 20 human KRAS-mutant NSCLC (non-small cell lung cancer) cell lines Hata and collaborators show that most human KRAS-mutant cell lines fail to undergo marked apoptosis in response to AZD6244 (Selumetinib, a potent, selective, and ATP-uncompetitive inhibitor of MEK1/2 kinases) [107] in combination with GDC-0941 (an orally bioavailable inhibitor of class I PI3K) [108], thus suggesting that failure to induce apoptosis may limit the efficacy of combined MEK and PI3K inhibition for KRAS-mutant NSCLCs. The gene discussed is MAP2K1; the disease is non-small cell lung carcinoma.