For example, Ma et al. found that, compared to normal cells, miR-138 expression is frequently reduced in gallbladder carcinoma cells and that miR-138 overexpression inhibits cell proliferation by directly suppressing BAG-1 expression [20]; Long et al. reported that miR-138 downregulation in human colorectal cancer (CRC) may be a new CRC prognostic biomarker, as miR-138 suppresses CRC cell migration and invasion, at least in part, by inhibiting the oncogene TWIST2 [21]. This evidence concerns the gene BAG1 and gallbladder carcinoma.