Secondly, we performed this analysis in RA patients only (n = 3 patients in remission; n = 57 patients with active disease) and found that C1M, C3M and CRPM were significant with an AUROC of 0.84 (95% CI 0.68 to 1.00), 0.94 (95% CI 0.87 to 1.00), and 0.91 (95% CI 0.80 to 1.00), respectively. Here, SH3BP2 is linked to rheumatoid arthritis.