In contrast, in mice with pancreatic cancer cells followed by Pseudomonas aeruginosa pneumonia, we found decreased apoptosis in both T and B lymphocytes, increased gut epithelial apoptosis, increased bacteremia without alterations in local infection, and higher BAL IL-6 and IL-10 compared to previously healthy septic mice. The gene discussed is IL10; the disease is familial pancreatic carcinoma.