For example, mutations in inositol 5-phosphatase (OCRL) are associated with Lowe Syndrome and Dent Disease [4, 5], an inactivating mutation in PIP kinase type 1γ (PIPKIγ) is associated with Lethal Contractural Syndrome Type 3 (LCCS3) [6], and mutations in Fab 1, YOTB, Vac 1, and EEA (FYVE) finger-containing phosphoinositide kinase (PIKFyve) are associated with François-Neetens Mouchetée Fleck Corneal Dystrophy [7]. Here, PIKFYVE is linked to corneal dystrophy.