LGALS4 and colitis: Once binding to this epitope, galectin-4 promotes apoptosis of T cells in calpain-dependent manner and reduces the secretion of cytokines including IL-6, IL-8, IL-10, and IL-17, and then ameliorating the inflammation (Paclik et al., 2008a). Lately, another research found that the role of galectin-4 varied in different experimental colitis models (Mathieu et al., 2008).