We also investigated the methylation changes at the intergenic enhancer region of THBS2 in various cancers from the TCGA data (HumanMethylation450 BeadChIP) and found that the enhancer of THBS2 was significantly hypo-methylated in colon and liver cancers (Supplementary Figure S6B and S6D) but not in kidney and pancreatic cancers (Supplementary Figure S6C and S6E). Here, THBS2 is linked to cancer.