The C-index of the multivariate prognostic model based on TNM stage, Fuhrman grade, tumor necrosis and lymphovascular invasion was 0.867 and improved to 0.879 when the intratumoral GM-CSF expression was incorporated, which showed a better predictive ability of RFS than Leibovich scores (C-index 0.850). The gene discussed is CSF2; the disease is neoplasm.