In terms of monoclonal antibody against EGFR and nasopharyngeal carcinoma, an early study showed that radiotherapy plus cetuximab improved locoregional control, overall survival (49.0 months vs 29.3 months) and reduced mortality (hazard ratio for death, 0.74; P=0.03) without increasing the common toxic effects of the head and neck cancers [21]. The gene discussed is EGFR; the disease is head and neck cancer.