On multivariate analysis (Table 5) mGPS (HR 1.81, 95 % CI 1.20–2.72, p = 0.005), TNM stage (HR 2.28, 95 % CI 1.23–4.21, p = 0.009), and breaching the established CRP threshold of 150 mg/L on POD 4 (HR 2.42, 95 % CI 1.13–5.18, p = 0.023) were independently associated with disease specific survival after surgery for colonic cancer. This evidence concerns the gene CRP and malignant colon neoplasm.