HIF1A and cancer: It is interesting to note that the most up‐regulated gene (+497 fold) in HCT‐8/R cells was the carbonyl reductase 1 (CBR1), a NADPH‐dependent enzyme that catalyzes a large number of endogenous and pharmacological substrates, reported to be up‐regulated in response to HIF‐1α and to be able to protect cancer cells against hypoxia and anticancer drugs such as cisplatin and doxorubicin, by reducing oxidative stress 32, 33.