Observations performed by double immunofluorescence staining of CD11b and iNOS revealed a strong expression of iNOS by CD11b+ cells within the tumors of peptide R-treated mice, compared to control and Plerixafor-treated mice (Fig. 5a and b, Tumor core), suggesting that peptide R treatment promotes M1 properties in GAMs. This evidence concerns the gene NOS2 and neoplasm.