P-ACL IHC analysis of tissue array with normal breast (n = 8), hyperplasia (n = 10), invasive ductal carcinoma (n = 18) and invasive lobular carcinoma (n = 8) revealed a general trend for low staining in normal breast, a noticeably increased staining in hyperplasia and the highest P-ACL staining in invasive ductal and lobular carcinoma (Figure 2A, left). The gene discussed is ACLY; the disease is invasive lobular breast carcinoma.