Utilizing BMSC and HOB as just two representative elements of the protective BMM niche, we observed that co-culture reduces tumor cell BCL6 expression compared to ALL cells cultured in media alone (Figure 1) and that removal of ALL cells from the PD “niche” buried beneath BMSC or HOB to media alone results in increased BCL6 protein abundance (DNS). This evidence concerns the gene BCL6 and acute lymphoblastic leukemia.