First, we did an independent lineal regression analysis in BRCA1/2 mutation carriers to test whether cancer status (individuals with or without cancer antecedents) could affect TL and percentage of short telomeres; because it did not affect these 2 factors (Supplementary Table S3), we decided to include healthy and affected BRCA1/2 mutation carriers in the same group (BRCA1/2) for telomere studies. The gene discussed is BRCA1; the disease is cancer.