First, we did an independent lineal regression analysis in BRCA1/2 mutation carriers to test whether cancer status (individuals with or without cancer antecedents) could affect OGG1 mRNA levels; because it did not affect, we decided to include healthy and affected BRCA1/2 mutation carriers in the same group (BRCA1/2) for expression studies, Supplementary Table S3. Here, BRCA1 is linked to cancer.