However, we propose that the farnesylated carboxyl-terminus of progerin might dislodge CENP-F from its normal location at the metaphase kinetochore-microtubule interface, which weakens protein-protein interactions, and this may lead to defective chromosomal maintenance, increased lagging chromatin and aneuploidy in HGPS cells. This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.