We then found that HHIP promoter was epigenetically silenced in LAC, like previous reports in other cancer types [25–29], The analysis of 492 LAC patient samples showed that HHIP promoter was significantly hypermethylated in tumor, and the methylation level was significantly associated with gene expression (Supplementary Figure S2B and Supplementary Figure S2C). The gene discussed is HHIP; the disease is neoplasm.