After MALAT1 specific siRNA (si-MALAT1) was transfected in TE7 cells, we noted that the down-regulation of MALAT1 expression inhibited cell proliferation, migration, tumor sphere formation, while increasing esophageal cancer cell apoptosis in vitro, as the results reported by Wang et al [24], in which the abilities of migration and invasion of ESCC cells were inhibited after silencing MALAT1. The gene discussed is MALAT1; the disease is neoplasm.