GBA1 and lysosomal storage disease: After 30 hr, only 33% and 39% of the macrophages in the wild-type fish retained the dextran, whereas 77% and 79% did in the cathepsin and gba-deficient animals, respectively (Figure 6), suggesting that stalling of the entire endocytic system is a common feature of lysosomal storage diseases and underlies the defective migration displayed by vacuolated macrophages.